Doxorubicin-dependent skeletal muscle atrophy: exercise and mitochondrial dysfunction
Gökhan Burçin Kubat1, Meltem Tuncer2
1Department of Mitochondria and Cellular Research, Gülhane Health Sciences Institute, University of Health Sciences, Ankara, Türkiye
2Department of Physiology, Faculty of Medicine, Hacettepe University Ankara, Türkiye
Keywords: Doxorubicin, skeletal muscle atrophy, mitochondria, exercise
Abstract
Doxorubicin (DOX) is a type of chemotherapy with harmful side effects due to its accumulation in various tissues. DOX is widely known for having a significant effect on skeletal muscle atrophy. The most significant of these side effects is DOX-induced mitochondrial dysfunction in skeletal muscle atrophy. Exercise is a treatment approach that serves to maintain muscle homeostasis by decreasing or eliminating these effects. The goal of this review article is to give current knowledge on the causes of DOX-induced skeletal muscle atrophy, the basic processes involved in mitochondrial dysfunction caused by DOX, and the effects of exercise on DOX-induced skeletal muscle atrophy.
Cite this article as: Kubat GB, Tuncer M. Doxorubicin-dependent skeletal muscle atrophy: exercise and mitochondrial dysfunction. Turk J Sports Med. 2024;59(1):39-43; https://doi.org/10.47447/tjsm.0799
Concept - GBK; Design - GBK; Supervision - GBK, MT; Literature Review- GBK; Writing Manuscript – GBK, MT; Critical Reviews – GBK, MT
The authors declared no conflicts of interest with respect to authorship and/or publication of the article.
The authors received no financial support for the research and/or publication of this article.
