p-ISSN: 1300-0551
e-ISSN: 2587-1498

Ayhan Canbulut1, Sabriye Ercan1, Sefa Alperen Öztürk2, Alper Özorak2, Fevziye Burcu Şirin3, Hülya Mete Arıcan3, Cem Çetin1

1Sports Medicine Department, Faculty of Medicine, Süleyman Demirel University, Isparta, Türkiye
2Urology Department, Faculty of Medicine, Süleyman Demirel University, Isparta, Türkiye
3Medical Biochemistry Department, Faculty of Medicine, Süleyman Demirel University, Isparta, Türkiye

Keywords: Irisin, prostate cancer, isometric muscle strength, androgen deprivation therapy, physical function


Objective: Losses in muscle strength and decreases in physical functions, and therefore a decrease in quality of life, have been observed in prostate cancer patients receiving androgen deprivation therapy (ADT). Irisin is a new exercise-induced myokine, released from the muscles. It is predicted that muscle tissue irisin release as a result of muscle loss, may be affected in patients receiving ADT. The aim of this study is to compare irisin levels, together with muscle strength and physical functions, in patients receiving ADT, patients not receiving ADT, and healthy individuals.

Material and methods: A total of 21 healthy individuals (control group: CG); 28 local- or local-advanced prostate cancer patients, not receiving ADT (non-ADT group); and seven prostate cancer patients receiving luteinizing hormone releasing hormone agonist (ADT group) were included in the study. Blood biochemistry (lipid profile, hormones, prostate specific antigen, glucose, insulin, and creatine phosphokinase) and irisin analyses were conducted. Physical functions were assessed by using the Five Times Sit to Stand (5TSTS), climbing stairs, walking pace, and functional reach (FRT) tests. Lower extremity isometric muscle strength was measured using an isokinetic dynamometer.

Results: It was observed that the 5TSTS test results were higher (p=0.03), but FRT results were lower (p=0.04) in the ADT group. It was found that isometric muscle strength in lower extremities was significantly lower in the ADT group (p˂0.05). Plasma irisin levels did not reveal a significant difference between the groups (p=0.31).

Conclusion: It was determined that muscle strength and physical function test performances of prostate cancer patients receiving ADT were worse, but their irisin levels were similar to patients who were not receiving ADT, and the healthy CG. Muscle strength and physical functions of patients who are receiving ADT, and who will start receiving ADT should be monitored, and protective measures should be taken.

Cite this article as: Canbulut A, Ercan S, Ozturk SA, Ozorak A, Sirin FB, Mete Arican H, et al. Effect of androgen deprivation therapy on plasma irisin levels, muscle strength, and physical functions tests of lower extremities. Turk J Sports Med. 2023 58(2):67-73; https://doi.org/10.47447/tjsm.0716

Ethics Committee Approval

Suleyman Demirel University, Faculty of Medicine Clinical Research Ethics Committee (approval number: 38, date: 13.02.2020)

Author Contributions

Concept: AC, SE, SAÖ, AÖ, CÇ, FBŞ; Design: AC, SE, SAÖ, AÖ, CÇ, FBŞ; Supervision: SE, SAÖ, AÖ, CÇ, FBŞ; Materials: AC, SE, SAÖ, AÖ, CÇ, FBŞ; Data Collection and/or Processing: AC, SAÖ, AÖ, FBŞ, HMA; Analysis and Interpretation: AC, SE, SAÖ, AÖ, CÇ; Literature Review: All; Writing Manuscript: AC, SE; Critical Reviews: All

Conflict of Interest

The authors declared no conflicts of interest with respect to authorship and/or publication of the article.

Financial Disclosure

The authors received no financial support for the research and/or publication of this article.