THE EFFECTS OF REGULAR EXERCISE ON BLOOD PARAOXONASE AND ARYLESTERASE ACTIVITIES AND RELATIONSHIPS WITH PON1-192 POLYMORHISM

Abstract

The effects of regular leisure-time exercise on blood paraoxonase (PON1) and arylesterase activities (AE) that are found in HDL, and the relationship of exercise with PON1-192 polymorphism (PON1P) were investigated in this study. Males aged 40-55 participated in the study. The exercise groups were selected from healthy joggers (JG, n=20) and soccer players (SG, n=20) who had regularly trained for many years. The control group (CG, n=20) consisted of healthy sedentary persons. Serum basal PON1, salt-stimulated PON1 (SSPON1) and AE activities were analyzed by kinetic methods. Blood lipids, HDL-C and its’ subgroups were determined by enzymatic-colorimetric methods. Phenotype groups of PON1P were determined from the SSPON1/AE ratio. HDL-C values of R carrier (QR+RR) and RR exercise groups were higher than the those of CG (p<0.05). No such differences were found for the QQ exercise group, nor when comparing phenotypes of controls and exercise groups. No significant differences were found between exercise and control groups for PON1 and AE activities. But the PON1 activity of QQ phenotype exercise group was significantly higher than that of its control group counterpart. Whereas the same activity in the RR and R carrier (RR+QR) exercise groups was less than their controls’. No significant effect of jogging and soccer exercise on PON1 and AE activity was observed, but the effects of exercise on PON1 and HDL-C in phenotype groups was differing, pointing to the role of PON1-192 polymorphism.