Collagen type 1 gene (COL1A1) rs1800012 polymorphism in long and short distance runners
Celal Bulğay1
, Canan Sercan Doğan2, Ebru Çetin1, Tolga Polat2, Başak Funda Eken3, Orkun Akkoç4, Işık Bayraktar5,
Korkut Ulucan3
1Faculty of Sport Sciences, Gazi University, Ankara, Turkey
2Laboratory of Medical Genetics and Molecular Diagnosis, Üsküdar University, İstanbul, Turkey
3Department of Medical Biology and Genetics, Faculty of Dentistry, Marmara University, İstanbul, Turkey
4Department of Movement and Training, Cerrahpaşa Faculty of Sport Sciences, İstanbul University, İstanbul, Turkey
5Faculty of Sport Sciences, Alanya Alaaddin Keykubat University, Antalya, Turkey
Keywords: Injury risk, runners, COL1A1, polymorphism, sport genetics
Abstract
Objective: Understanding the genetic nature of injuries in athletes may be conceived as an important step in the prevention and rehabilitation process of the injuries. The aim of this study is to analyze the rs1800012 genotype and allele distribution of the collagen type I alpha 1 gene (COL1A1), which is effective in non-contact injuries of long distance and short distance runners.
Material and Methods: A total of 94 participants, including 19 long distance runners, 25 short distance runners and 50 sedentary individuals were enrolled in the study. Genomic DNA was isolated from oral epithelial cells using the Invitrogen DNA isolation kit (Invitrogen, USA) according to the manufacturers’ protocol. Genotyping was performed with real-time PCR.
Results: There were no statistically significant differences between long distance-short distance (p=0.870), short distance-sedentary individuals (p=0.510) and long distance-sedentary individuals (p=0.201) group variables in terms of genotype. Similarly, when the same groups were compared in terms of allelic distribution (respective p values 0.680, 0.337 and 0.201), there were no statistically significant differences.
Conclusion: In the study, it was found that GG genotype and G allele were higher for rs1800012 polymorphism than the other genotypes. Therefore, both athletes and sedentary individuals are considered to be less at risk of non-impact injury predisposition.
Cite this article as: Bulgay C, Dogan CS, Cetin E, Polat T, Eken BF, Akkoc O, et al. Collagen type 1 gene (COL1A1) rs1800012 polymorphism in long and short distance runners. Turk J Sports Med. 2021;56(1).28-32.; http://dx.doi.org/10.47447/tjsm.0469
The authors declared no conflicts of interest with respect to authorship and/or publication of the article.
The authors received no financial support for the research and/or publication of this article.
