REVIEW: THE EFFECTS OF EXERCISE ON DNA
Zuhal HAMURCU
Erciyes Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı, Kayseri
Keywords: DNA damage, exercise, 8-hydoxydeoyguanosine
Abstract
Regular physical exercise is known to be beneficial to health. However, the energy demand during physical exercise causes an increased oxygen uptake, which may increase the production of reactive oxygen species (ROS). Excessive ROS production may lead to damage of lipids, proteins and DNA. Some studies have investigated the influence of exercise on DNA. However, results of these studies are conflicting with each other. Some investigators observed an increase or decrease of DNA damage after exercise, while others reported no change. ROS have a role in the aetiopathogenesis of organ and tissue damage, and of various diseases. Reactive oxygen compounds may be the primary cause in some diseases or be the secondary result of other diseases. Therefore, the effects of high oxygen consumption during exercise on DNA are important. Mechanisms that underline DNA damage as a result of exercise are reviewed in the present article.
